PREVALENCE OF MENINGITIS IN YOUNG INFANTS 29-90 DAYS WITH SEPSIS IN ADDIS ABABA, ETHIOPIA

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Abstract


Introduction: Bacterial meningitis is among the most serious infections in infants with high mortality and morbidi-ty. Management of young infants with serious bacterial infections and the need of lumbar puncture (LP) is contro-versial unlike neonates and older children.
Objective: to determine magnitude of meningitis and associated factors in young Infants admitted with suspected sepsis in Addis Ababa.
Methods: Cross sectional study was done in young infants admitted to a tertiary center from 2013-2019 for suspect-ed sepsis. Data was abstracted from patient files using structured questionnaire and analyzed by SPSS-20. Logistic regression was used to determine associated factors and independent predictors of meningitis.
Results: A total of 230 infants were included with a male to female ratio of 1.2. Most (61%) presented with fever, respiratory symptoms and feeding intolerance. While 3/4th of them have LP performed the prevalence of meningitis was 17 %. Microbiologic tests were rarely used for etiologic diagnosis. Less than 5 % had confirmed bacterial meningitis, mostly gram negative bacteria.
Conclusion: Meningitis is common coexisting condition in infants with Systemic Inflammatory Response Syndrome (SIRS) despite low microbiologic confirmation. Complete septic work up with emphasis on microbiology should be the standard of care for all young infants with SIRS.
Key words: Young infants, Meningitis, SIRS, Lumbar Puncture.

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References


Charles G. Prober, Roshni Mathew. Acute Bacterial Meningitis beyond the Neonatal Period. In: Robert M. Kliegman, Bonita F. Stanton, Nina F. Schor, Joseph W. St Geme III, Richard E. Behrman, editors. Nelson textbook of pediatrics, 20th edition. Philadelphia: Elsevier; 2016.p. 2938-2945.

Luca Bedetti,Lucia Marrozzini,Alessandro Baraldi et al. Pitfalls in the diagnosis of meningi-tis in neonates and young infants: the role of lumbar puncture. The Journal of Maternal-Fetal & Neonatal Medicine. 2018; May 23; 32(23): 4029-4035.

ZT Abenet. Prevalence, etiology and antimicrobial susceptibility of bacterial neonatal men-ingitis at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia. [Master‘s the-sis].Semantic scholars, 2015.

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